30-day money-back guarantee on your first order
30-day money-back guarantee on your first order
The Dr. Perry backed daily routine made to go with your stimulant.
Stasis Day & Night is the first supplement system designed to be taken alongside stimulants, and it has been tested against placebo in adults who take them. Psychiatrist Dr. Perry Mandanis explains why he backs it.
4.8 · 1,513 reviews
30-day guarantee
By Perry Mandanis, M.D.
Triple board-certified psychiatrist · 35 years in ADHD care · Stasis scientific advisor
$79 every 25 days · Free shipping on your first order · 30-day money-back guarantee
The Dr. Perry backed daily routine made to go with your stimulant.
Stasis Day & Night is the first supplement system designed to be taken alongside stimulants, and it has been tested against placebo in adults who take them. Psychiatrist Dr. Perry Mandanis explains why he backs it.
4.8 · 1,513 reviews
30-day guarantee
By Perry Mandanis, M.D.
Triple board-certified psychiatrist · 35 years in ADHD care · Stasis scientific advisor
$79 every 25 days · Free shipping on your first order · 30-day money-back guarantee
How stimulants work in your body
Stimulants are highly effective and well-studied ¹ treatments. If yours is working, you feel it in the morning. You start the task, follow the conversation, and get things done.
They work partly by turning up the sympathetic nervous system, the fight-or-flight side of your biology. That can happen at the same time you feel calmer and more focused. Cortisol, your main stress hormone, is part of that system. In one controlled study, 70 healthy adults took 20 mg of d-amphetamine or placebo on separate days. Here’s what their cortisol did over the next few hours:
Cortisol after one dose
Salivary cortisol over the following 4.5 hours.
■ d-amphetamine 20 mg
■ Placebo
Salivary cortisol (µg/dL)
0.6
0.4
0.2
0.0
0
1
2
3
4.5
Hours after dose
Approximate group means redrawn from 1. White et al., 2006, Figure 1; error bars omitted.
What this tells us
An acute cortisol response happened. It doesn’t show long-term harm, and it doesn’t show a benefit from Stasis.
Cortisol is a normal, necessary hormone, and lower isn’t automatically healthier. For me this is a reason to take stress and recovery seriously while respecting a treatment that helps you. It is not a reason to be frightened of your medication.
You’ll also hear about oxidative stress, the balance between reactive molecules and your body’s antioxidant defenses. That’s part of why Stasis includes antioxidant nutrients like vitamins C and E. It’s a reason for the formula, not proof that Stasis prevents damage.
And you’ll hear dopamine depletion used to explain how people feel when a dose wears off. Feeling that way doesn’t prove the mechanism. The dose ending, poor sleep and missed meals all play a part. Stasis hasn’t been shown to replenish dopamine, and I’d be wary of anyone who says otherwise.
None of this means your medication is harming you. It’s a reason to support your body through the whole day, not only the hours your dose is working. That’s the gap Stasis was built for.
How stimulants work in your body
Stimulants are highly effective and well-studied ¹ treatments. If yours is working, you feel it in the morning. You start the task, follow the conversation, and get things done.
They work partly by turning up the sympathetic nervous system, the fight-or-flight side of your biology. That can happen at the same time you feel calmer and more focused. Cortisol, your main stress hormone, is part of that system. In one controlled study, 70 healthy adults took 20 mg of d-amphetamine or placebo on separate days. Here’s what their cortisol did over the next few hours:
Cortisol after one dose
Salivary cortisol over the following 4.5 hours.
■ d-amphetamine 20 mg
■ Placebo
Salivary cortisol (µg/dL)
0.6
0.4
0.2
0.0
0
1
2
3
4.5
Hours after dose
Approximate group means redrawn from 1. White et al., 2006, Figure 1; error bars omitted.
What this tells us
An acute cortisol response happened. It doesn’t show long-term harm, and it doesn’t show a benefit from Stasis.
Cortisol is a normal, necessary hormone, and lower isn’t automatically healthier. For me this is a reason to take stress and recovery seriously while respecting a treatment that helps you. It is not a reason to be frightened of your medication.
You’ll also hear about oxidative stress, the balance between reactive molecules and your body’s antioxidant defenses. That’s part of why Stasis includes antioxidant nutrients like vitamins C and E. It’s a reason for the formula, not proof that Stasis prevents damage.
And you’ll hear dopamine depletion used to explain how people feel when a dose wears off. Feeling that way doesn’t prove the mechanism. The dose ending, poor sleep and missed meals all play a part. Stasis hasn’t been shown to replenish dopamine, and I’d be wary of anyone who says otherwise.
None of this means your medication is harming you. It’s a reason to support your body through the whole day, not only the hours your dose is working. That’s the gap Stasis was built for.
Why I said yes to Stasis
I’ve spent 35 years working with people who have attention challenges. I’m triple board certified in psychiatry, I prescribe stimulants, and I take one myself. I wasn’t diagnosed until medical school, so I know how much the right treatment can matter.
Before Stasis, I had never promoted a supplement or worked with a supplement company.
Before I said yes, I wanted to know what was in the formulas and why, whether the ingredients had been studied in people at those doses, and whether anyone had tested the finished product. The last answer is what changed my mind.
“A person’s life is bigger than their output.”
Dr. Perry Mandanis
Why I said yes to Stasis
I’ve spent 35 years working with people who have attention challenges. I’m triple board certified in psychiatry, I prescribe stimulants, and I take one myself. I wasn’t diagnosed until medical school, so I know how much the right treatment can matter.
Before Stasis, I had never promoted a supplement or worked with a supplement company.
Before I said yes, I wanted to know what was in the formulas and why, whether the ingredients had been studied in people at those doses, and whether anyone had tested the finished product. The last answer is what changed my mind.
“A person’s life is bigger than their output.”
Dr. Perry Mandanis
How Stasis performed in a clinical trial
Stasis tested the finished Day & Night system in a randomized, triple-blind, placebo-controlled trial of 90 adults taking prescribed stimulants. Citruslabs ran it over three months, and nobody knew who was getting Stasis: not the participants, the coordinators, or the analysis team.
3 months
90 randomized
Triple-blind
Placebo-controlled
What people reported at month three
■ Stasis (n=35) ■ Placebo (n=38)
Personal relationships improved
Stasis
60%
Placebo
26%
Less brain fog
Stasis
69%
Placebo
39%
Clarity and focus improved
Stasis
77%
Placebo
50%
Self-reported agreement, rounded; 73 respondents analyzed. Selected exploratory outcomes, Citruslabs final report (Aug 6, 2026), Table 6. Funded by Stasis; not peer reviewed. NCT07380412.
The relationships result is the one that stays with me. Being more present with the people you love in the evening is exactly the kind of difference a person cares about.
I also wanted to know whether the reports changed with continued use. They did. For brain fog and appetite, the share of Stasis participants reporting a benefit grew each month, while placebo stayed roughly flat.
Reported benefits over three months
Stasis
Placebo
Less brain fog
0%
25%
50%
75%
100%
43%
57%
69%
43%
39%
39%
Month 1
Month 2
Month 3
Got appetite back
0%
25%
50%
75%
100%
32%
49%
57%
33%
39%
34%
Month 1
Month 2
Month 3
Respondents varied by month; lines connect group percentages, not individual changes. Citruslabs final report, Table 6.
Across a separate set of 11 symptom measures, all 11 favored Stasis at month three. In a trial this size, those differences didn’t reach statistical significance. I read that as an encouraging direction that deserves a larger study, and I’d rather tell you that plainly than oversell it.
How Stasis performed in a clinical trial
Stasis tested the finished Day & Night system in a randomized, triple-blind, placebo-controlled trial of 90 adults taking prescribed stimulants. Citruslabs ran it over three months, and nobody knew who was getting Stasis: not the participants, the coordinators, or the analysis team.
3 months
90 randomized
Triple-blind
Placebo-controlled
What people reported at month three
■ Stasis (n=35) ■ Placebo (n=38)
Personal relationships improved
Stasis
60%
Placebo
26%
Less brain fog
Stasis
69%
Placebo
39%
Clarity and focus improved
Stasis
77%
Placebo
50%
Self-reported agreement, rounded; 73 respondents analyzed. Selected exploratory outcomes, Citruslabs final report (Aug 6, 2026), Table 6. Funded by Stasis; not peer reviewed. NCT07380412.
The relationships result is the one that stays with me. Being more present with the people you love in the evening is exactly the kind of difference a person cares about.
I also wanted to know whether the reports changed with continued use. They did. For brain fog and appetite, the share of Stasis participants reporting a benefit grew each month, while placebo stayed roughly flat.
Reported benefits over three months
Stasis
Placebo
Less brain fog
0%
25%
50%
75%
100%
43%
57%
69%
43%
39%
39%
Month 1
Month 2
Month 3
Got appetite back
0%
25%
50%
75%
100%
32%
49%
57%
33%
39%
34%
Month 1
Month 2
Month 3
Respondents varied by month; lines connect group percentages, not individual changes. Citruslabs final report, Table 6.
Across a separate set of 11 symptom measures, all 11 favored Stasis at month three. In a trial this size, those differences didn’t reach statistical significance. I read that as an encouraging direction that deserves a larger study, and I’d rather tell you that plainly than oversell it.
How Stasis fits your day
Stasis isn’t a treatment for any diagnosed medical condition. It’s two formulas designed to be taken alongside the stimulant you already rely on. Two capsules each, and that’s the whole routine.
Daytime
2 capsules when you wake up, with your stimulant.
Nighttime
2 capsules about 30 minutes before bed.
When you manage a stimulant routine, simple matters. Out of sight becomes out of mind fast, so keep the jars where you keep your prescription. Each set has 25 days of both formulas.
30-day money-back guarantee on your first order
How Stasis fits your day
Stasis isn’t a treatment for any diagnosed medical condition. It’s two formulas designed to be taken alongside the stimulant you already rely on. Two capsules each, and that’s the whole routine.
Daytime
2 capsules when you wake up, with your stimulant.
Nighttime
2 capsules about 30 minutes before bed.
When you manage a stimulant routine, simple matters. Out of sight becomes out of mind fast, so keep the jars where you keep your prescription. Each set has 25 days of both formulas.
30-day money-back guarantee on your first order
As featured in
As featured in
Stasis Day & Night Set
Day for the morning, Night for the wind-down. 25 servings of each.
4.8 from 1,513 reviews
Choose your plan
Subscriptions renew automatically at the price and interval shown until you cancel.
30-day money-back guarantee
Free shipping on your first order
Third-party tested
Stasis Day & Night Set
Day for the morning, Night for the wind-down. 25 servings of each.
4.8 from 1,513 reviews
Choose your plan
Subscriptions renew automatically at the price and interval shown until you cancel.
30-day money-back guarantee
Free shipping on your first order
Third-party tested
What’s in Stasis, and why
What made me take the formula seriously is that I could follow the reasoning from the label to the research. Here are the three ingredients I’d point you to. Each is a study of a single ingredient, not proof that the full system does the same thing.
Shoden® ashwagandha, 120 mg
Drop in morning cortisol after 60 days.* 120 mg is the dose in Stasis Daytime.
Shoden
67%
Placebo
2.2%
60 adults with high stress and elevated morning cortisol, 20 per arm. Mishra & Kumar, 2024. Not a trial of Stasis or of stimulant users.
L-theanine
200 mg in Daytime and in Nighttime
A small four-week study of 200 mg a day found improvements in some sleep measures, like time to fall asleep.*
Venetron®
50 mg in Nighttime
A six-week placebo-controlled study at 50 mg reported better self-rated stress and sleep disturbance.* It was industry funded, and it didn’t beat placebo on its main anxiety measure.
Based on clinical studies of individual ingredients. Full Daytime and Nighttime labels are in the Day & Night Set details above.
What’s in Stasis, and why
What made me take the formula seriously is that I could follow the reasoning from the label to the research. Here are the three ingredients I’d point you to. Each is a study of a single ingredient, not proof that the full system does the same thing.
Shoden® ashwagandha, 120 mg
Drop in morning cortisol after 60 days.* 120 mg is the dose in Stasis Daytime.
Shoden
67%
Placebo
2.2%
60 adults with high stress and elevated morning cortisol, 20 per arm. Mishra & Kumar, 2024. Not a trial of Stasis or of stimulant users.
L-theanine
200 mg in Daytime and in Nighttime
A small four-week study of 200 mg a day found improvements in some sleep measures, like time to fall asleep.*
Venetron®
50 mg in Nighttime
A six-week placebo-controlled study at 50 mg reported better self-rated stress and sleep disturbance.* It was industry funded, and it didn’t beat placebo on its main anxiety measure.
Based on clinical studies of individual ingredients. Full Daytime and Nighttime labels are in the Day & Night Set details above.
Getting the most from your first 30 days
Before you start, pick one or two things you actually want to notice. Maybe it’s how you feel in the evening, how easily you wind down, or how you sleep. A few words in your phone is enough.
Give it consistent use, not a single day. If you don’t notice a difference worth having, that’s useful information, not another routine you failed at. That’s what the 30-day guarantee is for.
Getting the most from your first 30 days
Before you start, pick one or two things you actually want to notice. Maybe it’s how you feel in the evening, how easily you wind down, or how you sleep. A few words in your phone is enough.
Give it consistent use, not a single day. If you don’t notice a difference worth having, that’s useful information, not another routine you failed at. That’s what the 30-day guarantee is for.
Why I put my name on it
I came to Stasis skeptical, and I still ask questions. What I found was an approach I take seriously: start with the life of someone who takes a stimulant, think about both day and night, and test the finished system in a controlled trial. The evidence is still developing. The purpose matters to me.
Read the labels. Look at the research. Talk with someone who knows your history. Then decide if a trial makes sense for you.
Warmly,
Dr. Perry M.
Perry Mandanis, M.D.
Why I put my name on it
I came to Stasis skeptical, and I still ask questions. What I found was an approach I take seriously: start with the life of someone who takes a stimulant, think about both day and night, and test the finished system in a controlled trial. The evidence is still developing. The purpose matters to me.
Read the labels. Look at the research. Talk with someone who knows your history. Then decide if a trial makes sense for you.
Warmly,
Dr. Perry M.
Perry Mandanis, M.D.
Common questions
Stasis was developed with stimulant users in mind and is designed to be taken alongside them, but that doesn’t establish compatibility with every prescription or medical history. Ask your prescriber or pharmacist to review both labels and everything else you take. Don’t change a prescribed medication because of this page.
Common questions
Stasis was developed with stimulant users in mind and is designed to be taken alongside them, but that doesn’t establish compatibility with every prescription or medical history. Ask your prescriber or pharmacist to review both labels and everything else you take. Don’t change a prescribed medication because of this page.
Ratings and Reviews
4.8
Based on 1,513 reviews
Showing 8 of 1,513 reviews
Sort Featured
Ellen M.
Verified Buyer
Gave me back my social life
I used to love going out, but I'm usually too exhausted after work. After about a week on Stasis, I noticed a huge difference in my mood and overall well being. I have the energy to go to the bar after work, which I haven't done in years!
Was this helpful?
Jonathan A.
Verified Buyer
My wife was the first to notice the difference, even before me. Stasis allows me to stay neutral and balanced with my mood throughout the day.
Was this helpful?
Amra A.
Verified Buyer
I have been taking stimulants for years and this has changed everything. I would often struggle to fall asleep which would cause me to be tired and irritable the next day.
Was this helpful?
Vanessa M.
Verified Buyer
I was pretty skeptical of this supplement, but also pretty desperate to not have to give up my stimulant. After 2 weeks, I can't deny that it is extremely effective.
Was this helpful?
Marissa G.
Verified Buyer
I can wind down now after work and disconnect. I work from home so, I struggled for a long time with disconnect.
Was this helpful?
tory r.
Verified Buyer
I snap less at the end of the day. Was recently started on stimulant and noticed mood swings and increased temper at the end of the day.
Was this helpful?
Kim B.
Verified Buyer
I tried so many vitamins and lifestyle changes to even out my mood while taking a stimulant and stasis is the first thing that has really made a difference
Was this helpful?
Howard D. P.
Verified Buyer
Although not crazy super life changing, it has had a positive effect going into 3rd month of constant use. I think it has paired well with my [stimulant]
Was this helpful?
Verified buyer reviews, excerpted. Individual experiences; results vary. Bracketed words replace a medication name.
Ratings and Reviews
4.8
Based on 1,513 reviews
Showing 8 of 1,513 reviews
Sort Featured
Ellen M.
Verified Buyer
Gave me back my social life
I used to love going out, but I'm usually too exhausted after work. After about a week on Stasis, I noticed a huge difference in my mood and overall well being. I have the energy to go to the bar after work, which I haven't done in years!
Was this helpful?
Jonathan A.
Verified Buyer
My wife was the first to notice the difference, even before me. Stasis allows me to stay neutral and balanced with my mood throughout the day.
Was this helpful?
Amra A.
Verified Buyer
I have been taking stimulants for years and this has changed everything. I would often struggle to fall asleep which would cause me to be tired and irritable the next day.
Was this helpful?
Vanessa M.
Verified Buyer
I was pretty skeptical of this supplement, but also pretty desperate to not have to give up my stimulant. After 2 weeks, I can't deny that it is extremely effective.
Was this helpful?
Marissa G.
Verified Buyer
I can wind down now after work and disconnect. I work from home so, I struggled for a long time with disconnect.
Was this helpful?
tory r.
Verified Buyer
I snap less at the end of the day. Was recently started on stimulant and noticed mood swings and increased temper at the end of the day.
Was this helpful?
Kim B.
Verified Buyer
I tried so many vitamins and lifestyle changes to even out my mood while taking a stimulant and stasis is the first thing that has really made a difference
Was this helpful?
Howard D. P.
Verified Buyer
Although not crazy super life changing, it has had a positive effect going into 3rd month of constant use. I think it has paired well with my [stimulant]
Was this helpful?
Verified buyer reviews, excerpted. Individual experiences; results vary. Bracketed words replace a medication name.
About this article. Perry Mandanis, M.D., is a Stasis scientific advisor with a paid partnership. This article is published by Stasis. It is for informational purposes only and is not medical advice. Talk with your healthcare provider before starting a new supplement, especially if you have a medical condition or take medication.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
© Stasis · Balance for bold minds.
About this article. Perry Mandanis, M.D., is a Stasis scientific advisor with a paid partnership. This article is published by Stasis. It is for informational purposes only and is not medical advice. Talk with your healthcare provider before starting a new supplement, especially if you have a medical condition or take medication.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
© Stasis · Balance for bold minds.
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